Abstract
Herpes simplex virus encephalitis (HSVE) is an inflammation of the brain parenchyma caused by virus, leading to focal necrosis in medial temporal lobes, hippocampal complex and basal forebrain. Cognitively, HSVE is associated to many dysfunctions which vary according to the extent of the lesion. Episodic memory impairment is the most common sequelae following HSVE episodes, although others can occur. The aim of this case report was to describe the cognitive profile of a 42 year-old man who had extensive bilateral damage to the medial temporal lobe, insular bilateral and orbitofrontal cortices due to HSVE. Severe anterograde and retrograde amnesia, naming deficits, perseverative behaviors and confabulations were observed on neuropsychological assessment. We discussed the concept of long term-working memory based on this evaluation. These cognitive impairments corroborated HSVE previous findings in the literature.
Highlights
Herpes simplex virus encephalitis (HSVE) is an inflammation of the brain parenchyma caused by virus, leading to focal necrosis in medial temporal lobes, hippocampal complex and basal forebrain
The main theme of the confabulations was that he had come into hospital because he was working as a pharmaceutical manager
This study described a patient with cognitive dysfunction in episodic memory, language skills and executive functioning after an episode of HSVE
Summary
Abstract – Herpes simplex virus encephalitis (HSVE) is an inflammation of the brain parenchyma caused by virus, leading to focal necrosis in medial temporal lobes, hippocampal complex and basal forebrain. Episodic memory impairment is the most common sequelae following HSVE episodes, others can occur The aim of this case report was to describe the cognitive profile of a 42 year-old man who had extensive bilateral damage to the medial temporal lobe, insular bilateral and orbitofrontal cortices due to HSVE. Amnésia pós encefalítica com comprometimento da memória operacional de longo prazo: relato de caso Resumo – Encefalite herpética (EH) é uma inflamação do parênquima cerebral causada pelo vírus herpes e associada à necrose focal nos lobos temporais mesiais, formação hipocampal e nas partes basais do córtex préfrontal. The aim of this study was to report the case of a patient who developed severe retrograde and anterograde amnesia, dysexecutive symptoms and impairment on language skills after HSVE
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
