Abstract
Multiunit activity recorded in both the dentate gyrus and the entorhinal cortex during classical conditioning was studied in freely moving rats receiving a mild post-trial stimulation of the mesencephalic reticular formation. Dentate multiunit activity progressively increased in response to an auditory signal (conditioned stimulus) after pairing the signal with a footshock (unconditioned stimulus). No such increase was seen in the entorhinal cortex of the same animals during conditioning. Post-trial reticular stimulation facilitated the development of associative changes in dentate multinuit activity, while having no effect in the entorhinal cortex. The results were interpreted as indicating a possible specificity of action of post-trial reticular stimulation on learning-induced plasticity and are discussed in relation to the concept of neural perseveration in memory consolidation.
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