Post-Translational Modifications in Human Beta Myosin Heavy Chain

Abstract

Post translational modifications (PTM) modulate cell signaling and protein function and have been shown to fine-tune myocardial contractility. Acetylation plays a vital role in histone protein regulation in many cell types, including cardiomyocytes, but was subsequently found as a protein modification outside of the nucleus. Our interest is to further characterize the K-acetylation and S-, T-, and Y-phosphorylation found on the beta-myosin heavy chain (beta-MHC) protein in donor, ischemic, and non-ischemic human heart samples with the long-term goal of understanding the potential role of PTMs on cardiac function.