Abstract
Background HIV-1 gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously, we found, through a novel proteomic approach, that the nuclear matrix protein MATR3 is a cofactor of Rev mediated RNA export [Kula A et al.: Retrovirology 2011, 8:60]. More recently we demonstrated that pleiotropic polypyrimidine tract binding protein associated splicing factor (PSF) binds viral RNA and is associated with MATR3 [Kula A., Gharu L, Marcello A: Virology 2013, 435(2): 329-340].
Highlights
HIV-1 gene expression and replication are regulated at several levels
More recently we demonstrated that pleiotropic polypyrimidine tract binding protein associated splicing factor (PSF) binds viral RNA and is associated with MATR3 [Kula A., Gharu L, Marcello A: Virology 2013, 435(2): 329-340]
We propose that MATR3 and PSF define a novel pathway for RRE containing HIV-1 RNAs that is hijacked by the viral Rev protein
Summary
HIV-1 gene expression and replication are regulated at several levels. Spliced viral RNAs and full length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. We found, through a novel proteomic approach, that the nuclear matrix protein MATR3 is a cofactor of Rev mediated RNA export [Kula A et al.: Retrovirology 2011, 8:60]. More recently we demonstrated that pleiotropic polypyrimidine tract binding protein associated splicing factor (PSF) binds viral RNA and is associated with MATR3 [Kula A., Gharu L, Marcello A: Virology 2013, 435(2): 329-340]
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