Abstract
BackgroundAnxiety and depression are more frequent in cancer patients than general population and may be correlated with cancer prognosis; however, their value in prostate cancer patients is largely unknown. We aimed to evaluate prevalence of anxiety and depression in prostate cancer survivors post the surgeries, and their correlations with patients’ disease-free survival (DFS) and overall survival (OS).MethodsA hundred and ninety-four patients with prostate cancer who underwent radical prostatectomy were enrolled. After discharged from hospital, patients were assessed for post-surgery anxiety and depression every 3 months using Zung Self-rating Anxiety/Depression Scale (SAS/SDS) for a total of 36 months. In addition, disease conditions, DFS, and OS were also documented.ResultsSAS score (P < 0.001), anxiety rate (P = 0.004), SDS score (P < 0.001), and depression rate (P < 0.001) gradually elevated from baseline to month 36 in prostate cancer patients. Anxiety at baseline (P = 0.009) and anxiety at 3 years (P = 0.017) were correlated with worse DFS, and anxiety at baseline (P = 0.009) was also correlated with shorter OS in prostate cancer patients. Furthermore, depression at baseline (P = 0.005) and depression at 2 years (P = 0.008) were associated with unfavorable DFS, and depression at baseline (P = 0.001), 1 year (P = 0.025), and 2 years (P = 0.008) were associated with worse OS in prostate cancer patients. Moreover, multivariate Cox’s proportional hazards regression analysis elucidated that depression at baseline (P = 0.027) was an independent predictive factor for shorter DFS in prostate cancer patients.ConclusionAnxiety and depression both gradually deteriorate, and they correlate with unfavorable survival profile in prostate cancer patients after radical prostatectomy.
Highlights
Anxiety and depression have long been the most common mental disorders that impact on approximately 6–7% of the worldwide population, and they often coexist in the same individual [1, 2]
In each clinic visit, disease conditions and survival status of patients were documented for evaluation of disease-free survival (DFS) and overall survival (OS)
The anxiety was defined as SAS score ≥ 50; the depression was defined as SDS score ≥ 50 [18, 19]
Summary
Anxiety and depression have long been the most common mental disorders that impact on approximately 6–7% of the worldwide population, and they often coexist in the same individual [1, 2]. These mental disorders sabotage psychiatric health and result in physical dysfunction, such as increasing cardiovascular disease risk and cause fatigue in. We aimed to evaluate prevalence of anxiety and depression in prostate cancer survivors post the surgeries, and their correlations with patients’ disease-free survival (DFS) and overall survival (OS).
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