Post-prandial endothelial dysfunction is ameliorated following weight loss in obese premenopausal women

Abstract

SummaryBackgroundEndothelial dysfunction and postprandial hyperglycemia represent independent risk factors for cardiovascular diseases. Obesity is connected with endothelial impairments; however, it is unclear whether weight loss can modify endothelial function during the postprandial period. The aim of this study was to evaluate endothelial response (post-ischemic forearm blood flow, PIFBF) in a fasted state and following ingestion of 75g glucose before and after very low caloric diet (VLCD).Material/Methods40 obese premenopausal women (age 39.6±7.8 years, BMI 34.3±3.2 kg/m2) participated in 4-week very low caloric diet (VLCD, 800kcal/day). Before and after VLCD, the baseline blood flow and PIFBF were measured using a mercury strain gauge plethysmography in fasting state as well as 1 hour after ingestion of 75 g glucose.ResultsDietary intervention resulted in a 7% weight loss (p<0.05) and a decrease in insulin resistance index HOMA-IR (2.44±1.25 vs. 1.66±0.81, p<0.05). Before VLCD intervention, PIFBF following oral glucose challenge decreased by 8.2±9.1 ml/min/100 g tissue, while after weight loss identical stimulus increased PIFBF by 4.2±8.9 ml/min/100 g tissue (p<0.05). Plasma ICAM-1 and VCAM-1 decreased by 8% and 10%, respectively, throughout the study.ConclusionsPostprandial endothelial dysfunction is ameliorated following weight loss in obese women. This finding demonstrates the beneficial effects of weight reduction on atherosclerosis risk.