Abstract
To determine the time, extent and duration of the release of luteinizing hormone (LH), concentrations of LH were determined by radioimmunoassay in extracts of anterior pituitary glands and in sera drawn several times during the day from pregnant and post-partum rats. In the pregnant rat, no peaks in concentrations of LH in serum were found in 85 samples collected. Elevated concentrations of LH were seen as early as 2 hr after delivery, with the greatest percentage occurring between 7 and 10 hr after delivery. These elevated concentrations occurred as early as 7 AM on the day of delivery and as late as 3 in the morning of the day following delivery. Sequential samples from individual rats showed that the onset of the rise in serum LH occurred between 3 and 11 hr after delivery. The release of LH was rapid, with at least a 15-fold rise in concentration (and perhaps as much as a 60-fold increase) occurring in as little as 2 hr in some cases. The initial fall in serum LH concentrations was likewise rapid. The...
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