Abstract
Magnetic resonance imaging (MRI) allows noninvasive and non-destructive imaging of brain tissue. More specifically, the status of white matter fibers can be measured with diffusion-weighted MRI, enabling assessment of structural degeneration or remodeling of white matter tracts in diseased brain. Here, we describe the preparation of post-stroke rodent brain samples for post-mortem high-resolution 3D diffusion-weighted MR imaging, accompanied with guidelines for acquiring and processing the images.
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