Abstract
Post-kala-azar dermal leishmaniasis (PKDL) is a parasitic skin infection which can occur after visceral leishmaniasis (VL). Recent xenodiagnosis studies (Mondal et al., Clin. Infect. Dis., 2018) have uncovered the infectiousness of PKDL. When including this in a transmission model, PKDL cases appear as an important reservoir of infection, likely frustrating the VL elimination efforts on the Indian subcontinent.
Highlights
Post-kala-azar dermal leishmaniasis (PKDL) is a parasitic skin infection which can occur after visceral leishmaniasis (VL)
Dis., 2018) have uncovered the infectiousness of PKDL. When including this in a transmission model, PKDL cases appear as an important reservoir of infection, likely frustrating the VL elimination efforts on the Indian subcontinent
Kala-azar, commonly known as visceral leishmaniasis (VL), is a neglected tropical disease that has been targeted on the Indian subcontinent (ISC) for elimination as a public health problem by 2020, that is, a reduction of incidence to b1 VL case per 10 000 of the population per year atdistrict level
Summary
A.F. et al (2014) DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families. X. et al (2019) Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum.
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