Abstract
Methods A two-arm RCT was embedded into the follow-up of older adults as part of the UK Casper Plus trial and Casper Cohort. At 4 months follow-up, participants were randomised to receive either a questionnaire or a questionnaire + post-it note requesting completion. Logistic regression and time-to-event analyses were used to assess attrition. Results were combined with those of a previous embedded RCT (ATLAS) in a meta-analysis.
Highlights
Valid treatment effect estimates in the analysis of RCTs using patient reported outcomes depend on adequate response rates
Post-it notes were not found to be effective in improving retention in this trial
266 of 297 (89.6%) participants returned their questionnaire in the post-it note arm, compared with 282 of 314 (89.8%) in the control arm
Summary
Valid treatment effect estimates in the analysis of RCTs using patient reported outcomes depend on adequate response rates. Post-it notes to improve questionnaire response rates in RCTs - findings from a randomised sub-study Ada Keding*, Helen Lewis, Kate Bosanquet, Simon Gilbody, Hannah Buckley, Helen Tilbrook, David Torgerson From 3rd International Clinical Trials Methodology Conference Glasgow, UK.
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