Abstract
Laser-Doppler flowmetry (LDF) provides a continuous measurement of tissue microvascular blood flow in different pathophysiological situations. The aim of this study was to compare the perfusion signal (velocity multiplied by the concentration of moving red blood cells) and the CMBC signal (concentration of moving red blood cells) in the reperfusion phase after total ischemia of skeletal muscle. These parameters were recorded simultaneously with a laser-Doppler flowmeter (Periflux PF2b) in anesthetized rats. The flowmeter probe was placed on the left gastrocnemius muscle surface, which was made ischemic for various periods of time (10–180 min). In the control situation, prior to ischemia, the natural resting fluctuations of the perfusion and CMBC signals were parallel. Similarly, after release of ischemia there was an immediate and parallel increase in both the perfusion signal and the CMBC signal. The correlation coefficient between the perfusion signal and CMBC signal was found to be 0.78 ( P < 0.01). These results show that in the hyperemic phase after ischemia in skeletal muscle there is a close relationship between the perfusion signal and the CMBC signal recorded with LDF.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
