Abstract
The respiratory response to brief episodes of hypoxia is dynamic, i.e., the breathing pattern changes progressively both during and following an hypoxic episode1. The initial response in breathing with hypoxic exposure includes a sharp and acute increase in breathing frequency (F). Subsequently, F decreases as exposure to hypoxia continues. This decrease in F is a form of short-term depression that is referred to as “hypoxic ventilatory decline.” Immediately after the cessation of hypoxia and return to hyperoxic gas, F decreases further below the baseline frequency; the latter may be a form of short-term depression which is called post-hypoxic frequency decline (PHFD)1,2.
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