Post-gamma globulin: Tissue distribution and physicochemical characteristics of dog post-gamma globulin

Abstract

An animal model (dog) was established to investigate physicochemical and biological parameters of a basic low molecular mass protein-post-gamma globulin (p-f). In this study the distribution of this 11000 daltons (11 kdaltons) protein was determined in extracts of a number of tissues. Extracts of parotid gland, brain and kidney contained high amounts of “free” p-γ globulin (11 kdaltons). Two higher molecular mass forms (34k and 27 kdaltons) of this protein were demonstrated in the kidney and brain extracts. Extracts of ovary and uterus were devoid of the 27 k moiety and kidney extracts lacked the ‘free’ p-γ globulin (11k). These studies indicate that p-γ globulin may be a part of a much larger molecule or that p-γ globulin may be associated with another yet unknown protein. These findings may be important for clinical and pathological studies in human kidney and central nervous system (CNS) diseases.