Abstract
<br>To report evaluation and management of graft-host interface keratitis post-Descemet's membrane endothelial keratoplasty (DMEK). A 70-year-old lady with pseudophakic bullous keratopathy who underwent DMEK and developed interface interstitial keratitis on the first postoperative day. Cultures of corneal button revealed gram-negative bacilli (<i>Pseudomonas aeruginosa</i>). Prompt surgical intervention in the form of removal of donor Descemet's membrane and targeted antibacterial therapy helped in the complete resolution of infection. Descemet's stripping endothelial keratoplasty (DSEK) was performed postresolution of infection which yielded a good visual outcome for the patient. Donor rim culture helps immensely in identifying organisms in cases presenting in the early postoperative period.<br>
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