Post Covid Auto Immune Mediated Encephalopathy by Caspr2 Auto Antibody: The Report of Neurological Division o f “Carlo Poma Civil” Hospital of Mantua

Abstract

A recent cross sectional study ( Liu, 2021 ) suggests that SARS CoV 2 infection has a potential long term impact on the cognition of patients: we have to face with post covid syndrome and with long covid syndrome, the first characterized by symptoms in regression after an year by infection, the last with persisting symptoms after an year by infection. As the COVID 19 pandemic is still raging in many countries and is expected to last for a long period, the long term cognitive sequelae may bec ome a major publi c health issue long after the pandemic has ended. Longitudinal studies to follow up patients who have recovered from COVID 19 are necessary for better understanding the long term cognitive consequences of COVID 19, particularly among those who have recovered from severe disease. But these are not the unique problems of the so called NEUROCOVID. Neuromuscular manifestations of new coronavirus disease 2019 (COVID‐19) infection are frequent, and include dizziness, headache, myopathy, severe (also axonal) Gui llain Barrè Syndrome and olfactory and gustatory disturbances. Patients with acute central nervous system disorders, such as delirium, impaired consciousness, stroke and convulsive seizures, have a high mortality rate ( Shimohata, 2022 An other severe condition is rappresented by autoimmune encefalopathies COVID related. The encephalitis/encephalopathy that causes consciousness disturbance and seizures can be classified into three conditions, including direct infection with the SARS‐CoV‐2 v irus, encephalopa thy caused by central nervous system damage secondary to systemic hypercytokinemia (cytokine storm) and autoimmune‐mediated encephalitis that occurs after infection.