Abstract
Biochemical etiology of M. lepromatous suggests binding to a sialyl group on the endothelial cell surface. This binding is known to occur for binding of ICAM 1, VCAM 1 and VLA 4 to TLR-2. Post translational modification on TLR 2, on the cell surface and which initiates cell’s immune response, is, here, postulated to contain a sialyl group for binding to M. lepromatous. We hope bBinding of M. lepromatous to sialyl (α2->3) galactosyl (β 1->4) linked TLR-2, on human gut endothelial cells is may be prevented with ingestion of bovine milk because of the presence of sialylated lactose 6’ phospho di-phospho asparaginyl sulfo tyrosine dipeptide in bovine milk. To establish the structure of this bovine milk component through the use of mass spectrometry and high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) is sought. And thereby propose the use of bovine milk to treat M. lepromatous. Since no viable way to test bovine milk components for binding to M. lepromatous due to the difficulty of culturing the microbe testing in humans is suggested to be done. Here, to we characterize the structure of milk oligosaccharide, which is essential to moving forward with treatment of M. lepromatous infection with bovine milk.
Highlights
Mycobacterium lepramatous infection causes leprosy and its effects are devastating to those infected
TLR-2 on endothelial cells binds to M. lepramatous as a cell entry mechanism for the organism via an epitope thought to contain sialyl groups
[5] This derivative from bovine milk may act as a TLR 2 mimetic to prevent M. lepromatous infection
Summary
Mycobacterium lepramatous infection causes leprosy and its effects are devastating to those infected. A sialylated oligosaccharide could be used to mimic TLR-2[1, 2], on endothelial cell surfaces to bind M. lepromatous, to prevent infection by this microbe. The isolation, [3] and structural characterization, by the techniques noted previously[4] for proposed new structure for the major component of bovine milk is described. This molecule is N acetamido deoxy neuraminyl (α 2->3) 6’phospho galactosyl (β 1->4) glucosyl di-phospho aspariginyl sulfo tyrosine dipeptide. Jesus’ Christus and Michael Arden Madson: Possible Treatment of Mycobacterium Lepramatous with Bovine Milk body would be alleviated due to the known safety of bovine milk
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