Abstract

Possible therapeutic approach to apoptosis correction in nephrotic children

Highlights

  • Nephrotic-range proteinuria is the loss of 3 grams or more per day of protein into the urine or on a single spot urine collection, the presence of 2 g of protein per gram of urine creatinine

  • Detailed analysis shows that levels of BcL-xL decrease gradually depending on kidney function impairment

  • A reduction in proteinuria is associated with a slower decline in glomerular filtration rate (GFR)

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Summary

Introduction

Nephrotic-range proteinuria is the loss of 3 grams or more per day of protein into the urine or on a single spot urine collection, the presence of 2 g of protein per gram of urine creatinine. Nephrotic syndrome is the combination of nephrotic-range proteinuria with a low serum albumin level and edema. Nephrotic syndrome has many causes, including primary kidney diseases such as minimal-­change nephropathy, focal glomerulosclerosis, and membranous nephropathy. Nephrotic syndrome can result from systemic diseases that affect other organs in addition to the kidneys, such as diabetes, amyloidosis, and lupus erythematosus. Nephrotic syndrome may affect adults and children of both sexes and of any race. It may occur in typical form, or in association with nephritic syndrome. The latter connotes glomerular inflammation, with hematuria and impaired kidney function [1]

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