Abstract
Spironolactone is a well-known drug with many indications. In dermatology, it may be used for treating androgenetic alopecia with a high androgen level. A patient with idiopathic papilledema that was inactive for many years experienced a significant increase in intracranial pressure after receiving spironolactone. The symptoms were resolved soon after the medication was discontinued. This report draws physicians’ attention to such rare adverse events that may have unwanted consequences.
Highlights
Female androgenetic alopecia (AGA) is a well-known hair disorder that mostly affects middle-aged women [1]
Spironolactone-containing drugs are associated with many side effects, including orthostatic hypotension, electrolyte imbalance, menstruation irregularity, breast tenderness, hematological disorders, urticaria and fatigue [2]
We report this case with a possible rare side effect of spironolactone in a patient treated for female pattern hair loss due to unknown mechanism and with chronic intracranial hypertension (IIH)
Summary
Female androgenetic alopecia (AGA) is a well-known hair disorder that mostly affects middle-aged women [1]. Several pharmacological treatments for AGA are available, including spironolactone which displays an antiandrogenic effect. Spironolactone-containing drugs are associated with many side effects, including orthostatic hypotension, electrolyte imbalance, menstruation irregularity, breast tenderness, hematological disorders, urticaria and fatigue [2]. An increase in the intracranial pressure is rare, but may occur after consuming spironolactone. We report such an adverse effect of spironolactone along with literature review
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