Abstract
P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine associations between a germ-line polymorphism in the MDR1 gene with differentiated thyroid carcinoma (DTC). In the current case-control study, 60 differentiated thyroid cancers (DTC)- 45 papillary TC (PTC), 9 follicular TC(FTC) and 6 well-differentiated tumors of uncertain malignant potential (WDT-UMP) were examined. Results were compared to a healthy control group (n=58) from the same population. Genomic DNA was extracted from peripheral blood with EDTA and the target gene was genotyped by real-time PCR. Carriers of the variant allele of MDR1 exon 26 polymorphism were at 2.8-fold higher risk of DTC than the control group (odds ratio [OR]: 0.3805, 95% confidence interval [Cl]: 0.1597-0.9065 (p> 0.046). Presented results suggest that the MDR1 3435TT genotype might influence risk of development of DTC and that the CC genotype might be linked to a poor prognosis. Large-scale studies are now needed to validate this association.
Highlights
The differentiated thyroid cancer (DTC), the most common type of all thyroid cancers accounts for >90%
In the current case-control study it was aimed to find out the association between germ-line point mutations in MDR1 gene and thyroid carcinomas
By multiplex Realtime PCR technique, we evaluated common single nucleotide polymorphisms (SNPs) 3435 C>T for MDR1 gene in DTC patients and results were compared to the healthy controls (Figure 1)
Summary
The differentiated thyroid cancer (DTC), the most common type of all thyroid cancers accounts for >90%. The current preliminary study was designed to determine associations between a germ-line polymorphism in the MDR1 gene with differentiated thyroid carcinoma (DTC). By the current case-control study we wished to explore the possible role of the xenobiotic transporter P-glycoprotein polymorphism (encoded by the MDR1 gene) that is known as the transport dietary carcinogen in the susceptibility of differentiated thyroid cancer.
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