Abstract
Background IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. It acts as an alarmin, released by damaged cells. Binding to a ST2 receptor, it stimulates many immune cells such as ILC2 and Th2 cells. IL-33/ST2 axis seems to be involved in Th17 response. According to this, a review was performed to analyze if IL-33 even interplay in the onset of psoriasis, a Th1/Th17 inflammatory disease. Methods Data obtained from the included articles are study author name, publication date, group studied, clinical and biological variables, laboratory tests, and outcome of interest of the study. Results Data are obtained from the 19 studies identified, which assessed the association between IL-33 and psoriasis. Discussion It seems to promote the innate-adaptive immune crosstalk: it could induce mast cells and neutrophil response after being released by injured keratinocytes and after stimulation by some cytokines, in particular TNFα, INFγ, and IL-17A. In addition, it seems to be involved from the onset of disease to the development of comorbidities, as psoriatic arthritis. Conclusion The core of the future research on psoriasis could be to fully understand the role of this complex cytokine, in order also to find a new therapeutic approach.
Highlights
Interleukin-33 (IL-33) is a member of the IL-1 family, which includes other 11 members such as IL-1α, IL-1β, IL-18, IL-36, IL-37, and IL-38
Data are obtained from the 19 studies identified, which assessed the association between IL-33 and psoriasis
In a following article by the same authors, they found that IL-33 in normal skin is expressed by the endothelial cells, but in psoriatic skin, it is even present in the nucleus of KC, within the suprabasal layer to the stratum spinosum [29]
Summary
Interleukin-33 (IL-33) is a member of the IL-1 family, which includes other 11 members such as IL-1α, IL-1β, IL-18, IL-36, IL-37, and IL-38. IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies It acts as an alarmin, released by damaged cells. It seems to promote the innate-adaptive immune crosstalk: it could induce mast cells and neutrophil response after being released by injured keratinocytes and after stimulation by some cytokines, in particular TNFα, INFγ, and IL-17A. It seems to be involved from the onset of disease to the development of comorbidities, as psoriatic arthritis. The core of the future research on psoriasis could be to fully understand the role of this complex cytokine, in order to find a new therapeutic approach
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