Abstract
The emergence of new severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) has been a global concern. The B.1.1.7 variant of SARS CoV-2 is reported to cause higher transmission. The study investigates the replication cycle and transcriptional pattern of the B.1.1.7 to hypothesis the possible role of different genes in viral replication. It was observed that the B.1.1.7 variant required a longer maturation time. The transcriptional response demonstrated higher expression of ORF6 and ORF8 compared to nucleocapsid transcript till the eclipse period which might influence higher viral replication. The number of infectious viruses titer is higher in the B.1.1.7, despite a lesser copy number than B.1, indicating higher transmissibility. The experimental evidence published linked ORF6 and ORF8 to play important role in replication and we also observed their higher expression. This leads us to hypothesis the possible role of ORF6 and ORF8 in B.1.1.7 higher replication which causes higher transmission.
Highlights
Academic Editors: Dóra Tombácz and Lawrence S
The recent identification of the new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) variants has been of public health concern globally, after its first report from
The growth kinetics study for the SARS CoV-2 demonstrates a similar trend to SARS-CoV, where the virus was observed in the supernatant from 7th hpi [5].Further, limited data is present on the transcriptional response of the SARS CoV-2 proteins after it infects a host cell [5,6,7,8] at different time-points
Summary
Academic Editors: Dóra Tombácz and Lawrence S. Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The recent identification of the new Severe Acute Respiratory Syndrome Coronavirus-2. (SARS CoV-2) variants has been of public health concern globally, after its first report from
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
