Abstract
Due to rapid industrialization and technological development, humans are constantly exposed to heavy metals at minimum to maximum tolerable levels. Arsenic is ubiquitously distributed and most concerned element now-a-days, inorganic arsenicals mainly enter into the body via the route of lungs and gastrointestinal tract and 55-95% of it gets absorbed. Sodium arsenite poisoning leads to disturbance in hematological and biochemical processes. In the present study, toxic effects of sodium arsenite on the hematological parameters, serum transaminases and possible modulatory role of aqueous tomato extract were studied. Female rats were allocated into four different groups: 1. Control (given normal diet), 2. Sodium arsenite treated (10mg/kg B.W.), 3. Combination of sodium arsenite (10 mg/kg B.W.) and aqueous tomato extract (50 mg/kg B.W.) treated rats 4. Only aqueous tomato extract treated (50mg/kg B.W.) rats. It was observed that arsenic significantly decreased the total erythrocytes count (RBC), hemoglobin concentration (Hb), hematocrit value (HCT) and platelets (PLT), whereas significantly elevated the total leucocytes count (TLC) and activities of serum transaminases such as ALT and AST. Supplementation of aqueous tomato extract to arsenic treated rats showed decrease in values of WBC, ALT and AST which almost matched to values of control rats. So, from this study it can be concluded that antioxidants and vitamins present in the aqueous tomato extract showed protective role against arsenic toxicity in albino rats.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
