Abstract
Ciprofloxacin, which is a second generation of fluoroquinolone and one of the most effective and widely used drugs within fluoroquinolone. Unfamiliar adverse effects of ciprofloxacin such as bone marrow (BM) suppression, thrombocytopenia, anemia, agranulocytosis, renal failure, and others observed. Lutein, is a xanthophyll (an oxygenated carotenoid), was focused by most studies as it has a strong antioxidant activity in vitro; and also, it has been associated with reducing the risk of the age-related disorders. The current study was designed to describe the role of apoptosis through the measurement of Bcl-2 associated X protein (Bax) marker, as mechanisms of bone marrow toxicity induced by ciprofloxacin and to find whether lutein may have protective effects on ciprofloxacin-induced toxicity in bone marrow of rats. Ciprofloxacin (Group II) caused significant (P<0.05) reduction in total RBCs counts and -WBCs, and significantly elevations (P<0.05) Bcl-2 associated X protein (Bax) in bone marrow (BM) tissues homogenates compared to control (Group I) rats.
Highlights
The carboxylic acid derivation of fluoroquinolones is Ciprofloxacin, which is a second generation of fluoroquinolone and one of the most effective and widely used drugs within fluoroquinolone (1)
This study was designed to describe the role of apoptosis as mechanisms of bone marrow (BM) toxicity induced by ciprofloxacin; and to explore the possible protective effects of high- and low- doses of lutein against ciprofloxacin-induced toxicity in BM of rats
Administration of lutein at a dose of 6mg/kg body weight, and 24mg/kg each in association with ciprofloxacin (Groups V and VI) produced significant (P
Summary
The carboxylic acid derivation of fluoroquinolones is Ciprofloxacin, which is a second generation of fluoroquinolone and one of the most effective and widely used drugs within fluoroquinolone (1). A possible molecular mechanism provided for adverse effects of the ciprofloxacin was mentioned by researchers to be provoked by the inhibition of mitochondrial topoisomerase II (DNA-gyrase) that can lead to impairment of mitochondrial DNA transcription and replication, has an impact on the cellular differentiation and proliferation (5). Lutein was focused by most studies as it has a strong antioxidant activity in vitro; and it has been associated with reducing the risk of the age-related disorders (12). It is a xanthophyll (an oxygenated carotenoid), which in all mammalians including humans, that are unable to synthesize it but deriving it through their diet (14).
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