Possible Protective Effect of Silver Nanoparticles against Cisplatin Induced Pulmonary Inflammation in Rat Model

Neveen A Salem,Nawal W Helmi,Hanan Y Alharbi

doi:10.9734/jpri/2021/v33i46a32888

Abstract

Silver nanoparticles (AgNPs) are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. AgNPs possess remarkable anti-inflammatory and antioxidant activities and enhances wound healing. The main objective of the current study was to investigate the therapeutic effect of administration of AgNPs on cisplatin (CP) induced pulmonary inflammation in rats. Sixty male albino rats were used in this study. Rats were divided into 6 groups (n=10). Group I control group. Group II and III control groups received AgNPs at doses (5 and 10 ppm). Group IV CP group received CP (2.5 mg/kg). Group V and VI CP group received AgNPs (5, and 10 ppm). All doses were administered intraperitoneally once a day for 4 weeks. Oxidative stress and antioxidant status, inflammatory mediators, fibrogenic as well as apoptotic markers were determined in lung tissues. The results revealed that rats treated with CP showed remarkable elevation in lung tissues MDA, TNF-α, IFN-γ, IL-6, CRP, Fibrinogen and P53 levels associated with depression in SOD, GSH and CAT activities. However, administration of AgNPs (5 or 10 ppm) to CP group resulted in significant amelioration of the aforementioned parameters in a dose dependent manner. Histopathological investigation of lung tissues of CP group demonstrated disruption of normal lung architecture and lung injury. However, treatment with AgNPs revealed significant improvement in lung tissue against CP- induced inflammatory changes and lung tissue damage. It could be concluded that AgNPs exert potent cytoprotective effects via combating oxidative stress, inflammation, fibrogenic and apoptotic markers and repairing histopathological changes in lung tissues.

Highlights

Alharbi et al.; JPRI, 33(46A): 453-463, 2021; Article no.JPRI.75254 significant improvement in lung tissue against CP- induced inflammatory changes and lung tissue damage
The results revealed that rats treated with CP showed remarkable elevation in lung tissues MDA, TNF-α, IFN-γ, Interleukin -6 (IL-6), Creactive protein (CRP), Fibrinogen and P53 levels associated with depression in superoxide dismutase (SOD), GSH and Catalase activity (CAT) activities
Treatment CP rats with AgNPs either 5ppm or 10 ppm significantly reduced these inflammatory mediators in a dose dependent manner as compared to CP treated group

Summary

Introduction

Alharbi et al.; JPRI, 33(46A): 453-463, 2021; Article no.JPRI.75254 significant improvement in lung tissue against CP- induced inflammatory changes and lung tissue damage. The reported side effects include oxidative stress, which affects the lungs and various other tissues and organs [4]. Interstitial inflammation, fibrosis, structural pulmonary damage, and other severe complications have been reported during cisplatin chemotherapy [5]. These adverse effects of cisplatin-induced pulmonary damage may be due to the ability of cisplatin to produce oxidant-induced inflammatory and fibrotic lesions in lungs [6]. The current pharmacological management of inflammation is mainly by two groups of drugs the steroidal anti-inflammatory drugs and the non-steroidal anti-inflammatory agents These conventional drugs are associated with numerous side effects that has compelled the need for identification of alternative substances that can resolve inflammation in a way that is homeostatic, modulatory and efficient. They possess a wide spectrum of action [11]

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