Possible Protective Effect of Ginger Extract and Beetroot Juice Against Cisplatin Induced Testicular and Cytogenetic Toxicity in Adult Male Albino Rats

Abstract

Background: cisplatin (Cis) is an efficient platinum-derived anticancer drug. It has been successfully used in clinical oncology against diverse types of cancers. Testicular toxicity of cisplatin is of great concern because of increasing number of longer survival of cancer patients treated with cisplatin. Objective: the present study aimed to investigate the possible protective role of ginger extract and red beetroot juice against testicular and cytogenetic toxicity induced by cisplatin. Materials and Methods: sixty adult male albino rats were divided randomly into 6 groups (10 rats each). All groups were received the treatment once daily for 5 weeks, 4 days per week. At the end of experimental period samples were collected and then the levels of malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), and testosterone hormone were measured. Results & Conclusion: cisplatin treated animals recorded a significant increase in MDA level and a significant decrease in reduced glutathione (GSH) and catalase activities .Significant improvement occurred on co administration of GE or BRJ to cis treated animals .Significant decrease in serum concentration of testosterone in cis treated animals was recorded ,which improved significantly by co administration of GE or BRJ. A significant reduction in sperm count and motility and a significant increase in sperm head and tail abnormalities were noticed in cis treated animals which improved significantly on co-administration of GE or BRJ. Histopathological lesions which were observed in cis treated animals improved on co-administration of GE or BRJ. Finally BRJ caused more improvement in all theses parameters when compared with GE.