Abstract
Altered thyroid states may influence the effects of psychotropic drugs. Prange (1963a) reported a case in which moderate factitious hyperthyroidism and Imipramine treatment seemed to interact to produce paroxysmal auricular tachycardia. Later, this author and his colleagues described increased lethality in imipramine in hyperthyroid mice (Prange et al., 1962) and decreased lethality in hypothyroid mice (Prange et al, 1963b). Similar effects have been found for phenothiazines (Ashford et al., 1968). More recently it has been shown that a variety of physiological and behavioural effects of phenothiazines are amplified in hyperthyroid mice (Park et al., 1973). Furthermore, Selye and Szabo (1972) found that thyroxine sensitized the rat to the toxic effects of haloperidol.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.