Abstract

Electrical stimulation of tooth pulp produced excitatory and/or inhibitory responses in the neurones of the rat locus coeruleus (LC) sending axons to the dorsal noradrenergic pathway. The inhibitory response lasted for several hundred milliseconds and seemed to be triggered by the activation of axon-collaterals of the LC neurones, suggesting that the LC neurones have an important modulatory function in the information processing concerned with tooth pain.

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