Abstract
Alzheimer's disease is a sneaky-onset and progressive neurodegenerative disease characterized by the accumulation of senile plaques formed by amyloid β (Aβ) accumulated in the extracellular environment and intracellular hyperphosphorylated tau proteins characterized by progressive functional disorders and deaths of neurons. Recent studies suggest that the underlying cause of neurodegeneration may be disorders in axonal transport mechanisms. Axonal transport is a dynamic system required for neurons to communicate with each other, to fulfill neuronal functions and to survive. It performs these functions by transporting proteins, organelles, neurotrophic factors and neurotransmitter vesicles throughout the neuron. This system is protected and maintained by a large signal path that contains many proteins. However, by participating in the post-transcriptional regulation of many molecular mechanisms in the body, miRNAs that play a role in many other diseases, such as diseases based on the immune system, cancer and neurodegenerative diseases, can alter the expression of proteins in this signal pathway, leading to tau hyperphosphorylation, impaired axonal transport and hence Alzheimer's disease. In this review study, 12 strains of microRNAs such as miR-133, miR-224, miR-155, miR-34a, miR-125b, miR-9, miR-124, miR29-a/b/c, miR-10b and miR-132 have been investigated for their ability to participate in signaling pathways that play a role in axonal transport and their ability to participate Alzheimer pathology by causing tau hyperphosphorylation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.