Abstract
Numerous investigations indicate thatdiabetes mellitus is associated with pronounced changes in calcium homeostasis, which in turn lead to substantial complications in most systemic functions. However, similar combined investigations of possible alterations in calcium signalling in the nerve cells are lacking, although pathological changes in nervous functions, including paresthesia and increased pain sensitivity, are common complications ofdiabetes mellitus in humans. Therefore, we studied the changes in calcium homeostasis in sensory neurons of mice with streptozotocin (STZ)-induced and genetically determineddiabetes mellitus.
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