Abstract
The photosensitivity (phototoxicity) response in skin associated with protriptyline hydrochloride (PTL), a tricyclic antidepressant, was investigated. Ultraviolet irradiation of 1 × 10 −3 M solutions of PTL in phosphate-buffered saline resulted in a mixture of at least five products. Intradermal injection of irradiated PTL solutions elicited erythema and papules in epilated guinea pig skin. Irradiated PTL solutions also induced red blood cell lysis at dilutions up to 1:50. Photoproduct mixtures formed in the absence of oxygen produced stronger responses in both of these assays than those formed in the presence of oxygen. Unirradiated PTL solutions were negative. Photochemical studies demonstrated that the PTL photoproducts, which caused red blood cell lysis required water for their formation, were produced in higher yield in the absence of oxygen than in the presence of oxygen and were stable for at least 1 week.
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