Possible Kefir Biological Effects: 4: Effect of Kefir Beverage on The Histopathological and Macroscopical Changes in Adipose Tissue of High Fat-Fed STZ- Induced Diabetic Male Wistar Rat

Abstract

This study was designed to investigate the effect of kefir consumption as a common dairy fermented product on keep the bodyweight balanced on high fat-fed streptozotocin-induced diabetic wistar rats which fed with a daily kefir gavage dose, also to examine any effects regards the abdominal circumference (AC) and body fat mass; observed results compared to normal male rats; Experiments were carried out on 60 albino male rats, with age 8 weeks, weighing about 220-250 g, after the adaptation period, male rats were divided randomly into two experiments by six groups: experiment Ⅰ included 3 non-diabetic ones and experiment ⅠⅠ included three STZ induced diabetes groups. The groups were fed as follows: group 1 received a standard diet and served as control. Group 2 was fed on a standard diet and kefir (0.7 ml/animal/day by gavage). Group 3 received a high-fat diet and kefir (0.7 ml/animal/day by gavage). The diabetic males of groups A, B and C were fed on a high-fat diet. Group B received in addition kefir (0.7 ml/animal/day by gavage), while group C was injected additionally with insulin (0.76 UI/200 mg BW/day); all the groups have the access to the drinking water all the time.; the bodyweight of normal and diabetic rat males was determined on 1sttreatment day,and every week until the end the experiment plan (5 weeks) then all the groups were sacrificed with measuring the AC and weighting the fat mass; Summarizing it could be said; through all the work plan (5 weeks), all the six animal groups showed a significant increase in the mean body weight with a normal level in experiment Ⅰ unless in group 3 which fed on HFD and kefir, while in experiment ⅠⅠ kefir helps the diabetic treated group to not losing weight compared to the untreated one; similarity kefir neither affect AC nor relative fat weight.