Abstract
The effects of several convultants and diazepam on pentobarbital-stimulated gastric acid secretion were studied in the perfused stomach of rats under urethane anesthesia. Picrotoxin and pentylenetetrazol, GABA antagonists, and 3-mercaptopropionic acid, an inhibitor of GABA biosynthesis, strongly inhibited the pentobarbital-stimulated gastric acid secretion. The secretory action of pentobarbital was transiently depressed by strychnine, a glycine antagonist, and by bicuculline, a GABA antagonist; vigorous convulsions were observed in these rats. Diazepam had no effect on the pentobarbital-stimulated gastric acid secretion. These findings suggest that the potentiation of central GABAergic mediation by pentobarbital could be a main mechanism involved in pentobarbital-stimulated gastric acid secretion.
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