Abstract
A chemiluminescence study showed that Q i site inhibitors such as antimycin A induce O 2 − generation in respiring cyanide-sensitive mitochondria from the yeast, Hansenula anomala. The O 2 − generation was suppressed by radical scavengers such as flavone, butylated hydroxyanisole, and Co 0. Induction of cyanide-resistant respiration in H. anomala cells by Q i site inhibitors was also inhibited by these radical scavengers. Furthermore, antimycin A-induced synthesis of the mitochondrial 36-kDa protein, which is thought to be the alternative oxidase functional in the cyanide-resistant respiratory pathway, was abolished by the addition of flavone. These observations suggest that O 2 − is somehow involved in the induction of cyanide-resistant respiration.
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