Abstract
Purpose : To evaluate the synergistic or antagonistic interaction between oral dabigitran etexilate (Pradaxa) and some foods. Methods : Aqueous extracts of sweet orange, cabbage, ginger, green tea, garlic and pineapple were prepared and lyophilized, and total phenolic acids and flavonoid contents evaluated. The residues of the aqueous extracts were given daily to the rats (500 mg/kg dose, oral) 1 h after administration of dabigatran (1.83 mg/kg dose) for 14 days. Bleeding time, International Normalized Ratio (INR), prothrombin time (PT) as well as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in blood were measured. Results : Oral administration of Pradaxa with all the test food (except cabbage) significantly increased bleeding time, INR and PT. Pradaxa interaction with cabbage significantly decreased bleeding tendencies but the drug did not produce any major elevation of liver enzyme levels (ALT, AST and ALP). Conversely, significant elevation in ALP level was observed only after aqueous extract of ginger was administered with Pradaxa. Green tea and garlic significantly increased ALT and AST levels. Conclusion : Synergistic interaction occurrs between dabigatran etexilate with the selected foods, but interaction with cabbage antagonistic. Keywords: Dabigatran etexilate, Anticoagulant, Foods, Liver enzymes, International Normalized Ratio, Prothrombin time
Highlights
Anticoagulant drugs are those drugs that decrease the danger of blood clots
The animals were randomly distributed to eight groups (n = 6): group I (Control), received 1 % of CMC; group II, administrated Dabigatran etexilate in a dose of 1.83 mg/kg; groups III - VIII: administrated dabigatran etexilate in a dose of 1.83 mg/kg and after one hour they received the selected foods separately in a dose of 500 mg/kg suspended in 1% CMC
Evaluation of the total phenolic content of the selected foods aqueous extracts revealed that highest percentage yield was observed in green tea followed by pineapple (19.0, and 7.8 % respectively) calculated as gallic acid equivalents
Summary
Anticoagulant drugs are those drugs that decrease the danger of blood clots. Anticoagulants are used to treat atrial fibrillation and deep vein thrombosis. Dabigatran etexilate (Pradaxa) is a new oral anticoagulant drug with less side effects than other anticoagulant drugs (e.g., warfarin) [1]. Dabigatran is a direct thrombin inhibitors which inhibits free and clotbound thrombin and thrombin platelet aggregation. The drug is present in three strengths 75, 110 and 150 mg, and it is always taken two times daily by the patient [2].
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