Abstract
Some of the immunological effects of a variety of new quinolones on chemotaxis and the production of superoxide anion in rat macrophages were studied. All of the new quinolones examined at a dose range of 0.5 to 50 μg/ml significantly inhibited chemotaxis in a dose–dependent manner in rat macrophages. Moreover, the new quinolones at a dose of 0.5 μg/ml were effective in markedly potentiating the generation of superoxide anion. These results indicate that the new quinolones may modulate immune functions in rat macrophages.
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