Abstract
It cannot be expected that the use of fast neutrons instead of conventional radiation, will cause large improvements in cure rate of human tumours. Therefore controlled clinical trials of different types of tumours, requiring many years of observation will be necessary to assess possible gains. In addition to values from experiments with animal tumours, there is a need for clinical models which can provide quantitative data on the direct effects and on the RBE of fast neutrons in human tumours. The possibilities and properties of some of these models are discussed. Pulmonary metastases presumably offer the best possibilities for a comparative study of effects of photons and fast neutrons.
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