Abstract
Possible clinical implication of eosinophil extracellular traps in eosinophilic otitis media
Highlights
extracellular traps (EETs) were observed in the middle ear effusions of patients with Eosinophilic otitis media (EOM)
These findings allow us to speculate that EETosis can increase the viscosity of middle ear effusions and be a potential therapeutic target
Eosinophilic otitis media (EOM) is a newly recognized intractable middle ear disease that is characterized by the strong infiltration of eosinophils in highly viscous middle ear effusions and in the middle ear mucosa [1,2]
Summary
Eosinophilic otitis media (EOM) is a newly recognized intractable middle ear disease that is characterized by the strong infiltration of eosinophils in highly viscous middle ear effusions and in the middle ear mucosa [1,2]. Unlike conventional chronic otitis media (COM), the granulation tissue and highly viscous middle ear effusion of EOM are generally resistant to all therapies except for steroid treatment, and its aetiology is still ambiguous. 3),4) there are few reports of EETosis in EOM [5,6]. We recently reported that EETosis is evident in association with diverse eosinophilassociated diseases. We investigated the presence of EETosis in middle ear effusions of patients with EOM
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