Abstract
Δ 9-Tetrahydrocannabinol (THC), 11-OH THC, 8α,11-diOH THC, cannabinol (CBN) and cannabidiol (CBD) were examined for direct lipolytic activity on mouse adipocytes in vitro. None of the cannabinoids showed any marked stimulation of lipolysis, nor did they modify the response of the adipocytes to either isoprenaline or ACTH. In vivo, THC (but not CBN or CBD) produced in mice a dose-dependent rise in plasma non-esterified fatty acids (NEFA). This response was prevented by prior bilateral adrenalectomy or by pretreatment with α-methyl- p-tyrosine. Pretreatment with FLA-63 or phentolamine did not alter the lipolytic response to THC. However, the THC-induced rise in plasma NEFA was blocked by prior administration of the dopamine receptor antagonists perphenazine or pimozide. It is suggested that the elevation of plasma NEFA produced in mice by THC is centrally mediated and requires the presence of functional dopaminergic receptors.
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