Possible Benefits of the Coriandrum sativum in the Management of Diabetes in Animal Model: A Systematic Review

Frederico Ehff,Cardoso Albd

doi:10.21767/2472-0151.100010

Abstract

Diabetes mellitus (DM) is a group of a metabolic disease characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid, and protein metabolism, resulting from defects in insulin secretion, or action or both. DM caused at least 12% of global health expenditure is spent on diabetes ($ USD 673 billion). The control of diabetes with fewer side effects is a challenge. Authors have reported that herbal medicine would be an alternative to manage DM. Coriandrum sativum (Coriander) is a plant that has been used in the management of the diabetes. The purpose of this study was to review the published research concerning the use of coriander in the treatment of DM in animal models using a database. The papers were searched in the PubMed. It was verified a strong interest in studies involving diabetes. It is also observed that about 6.92% of the articles with the keyword “Coriandrum sativum” are related to diabetes. Five studies have reached the inclusion criteria to be analyzed. In all these investigations a reduction of the plasma level of glucose was detected in the animals treated with coriander. In conclusion, putting together the findings described in this study and considering the results in the publications, it is possible to conclude and to suggest that the use of coriander could be suitable to try to decrease plasma glucose level of diabetic animals. However, it is important to consider the limited number of publications available in the PubMed involving searches evaluating the antidiabetic effect of coriander

Highlights

Diabetes mellitus (DM) is a group of a metabolic disease characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid, and protein metabolism, resulting from defects in insulin secretion, or action or both [1,2]
Type 1 DM results from the body’s failure to produce insulin; Type 2 DM is due to insulin resistance, and gestational diabetes develops during pregnancy [4]
It is observed that about 6.92% of the articles with the keyword “Coriandrum sativum” are related to diabetes

Summary

Introduction

Diabetes mellitus (DM) is a group of a metabolic disease characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid, and protein metabolism, resulting from defects in insulin secretion, or action or both [1,2]. There are mainly three forms of diabetes: Type 1 DM, Type 2 DM, and gestational diabetes [3]. Type 1 DM results from the body’s failure to produce insulin; Type 2 DM is due to insulin resistance, and gestational diabetes develops during pregnancy [4]. The International Diabetes Federation (IDF) predicts that 415 million people world-wide have diabetes and by 2040 this will rise to 642 million. It is predict that 77% of people with diabetes live in low- and middle-income countries. The control of diabetes with fewer side effects is a challenge

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