Abstract

gamma-irradiated rat thymocytes were incubated in medium containing fresh rat serum. After 6 hours in culture, an equal dose dependency was noted for nuclear pyknosis and the loss of surface receptors to autologous erythrocytes. Decreased rosette formation preceded the expression of pyknosis. A possible relation between the membrane changes and pyknosis during interphase death of the thymocytes is discussed.

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