Abstract
Expression of compound metabolic enzymes is determined by polymorphism and may predispose the development of diseases aggravated by environmental factors. Glutathione S-transferase M1 (GSTM1) is an important phase II enzyme involved in the detoxification of many environmental carcinogens. GSTM1 status has been extensively studied as a risk factor for endometriosis, although inconsistent associations have been observed. To re-examine this controversy we designed a case-control study to determine the possible association between polychlorinated biphenyls (PCBs), phthalate esters (PEs) and GSTM1 null (∗0/∗0) mutation in the etiology of endometriosis.
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