Possible adsorption mechanism of high mobility group box 1 protein on a polyacrylonitrile (AN69ST) membrane filter

Osamu Nishida ,Kazuhiro Moriyama ,Taku Miyasho ,Yoshiharu Shimomura ,Miho Yumoto ,Shingo Yamada

doi:10.1186/cc10986

Osamu Nishida , Kazuhiro Moriyama + Show 4 more

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https://doi.org/10.1186/cc10986

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Abstract

At ISICEM 2011, we reported that AN69ST showed the highest capacity to adsorb high mobility group box 1 protein (HMGB1) when compared with polymethylmethacrylate, polysulfone and high cut-off membrane [1]. Here we focus on whether filtration or surface heparin on AN69ST by a priming circuit with a heparinized saline contributes to HMGB1, with a heparin-binding protein, adsorption on AN69ST.

Highlights

Sepsis is primarily a disease of the aged and 60% of sepsis occurs in patients older than 65 years, 80% of deaths due to sepsis occur in this age group
The purpose of the study is to elucidate the immunological changes that occur in Klotho mice after sepsis in order to identify therapeutic targets for sepsis that occurs in aged individuals
Forty-four septic patients and 48 gender-matched healthy volunteers were prospectively enrolled in the study, which included the following investigations: (1) The Sequential Organ Failure Assessment (SOFA) score and clinical outcome were compared between adult sepsis (

Summary

Introduction

Sepsis is primarily a disease of the aged and 60% of sepsis occurs in patients older than 65 years, 80% of deaths due to sepsis occur in this age group. The aim of this study was to determine the reasons behind out-of-hours discharges in our hospital and the effect this has on mortality This audit reviewed the discharge process of patients from an adult general ICU to the general wards before and after the introduction of a liaison nurse post over a 3-year, 3-month time period. The aim of this study was to establish and compare the quality and value of the summaries as judged by ICU doctors and GPs. The relationship between provider volume and patient outcome has been demonstrated for many medical and surgical services, including critical care. Methods In this single-centre observational study we aimed to quantify functional dependency at three different time points: discharge from ICU (DI), discharge from hospital (DH) and discharge from nursing home rehabilitation unit (DR) To this end we retrospectively assed Barthel scores (BS) for individual patients [1], with a duration of mechanical ventilation >48 hours.

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