Possibility of using thermal water from the Nizhne-Paratunskiye springs of Kamchatka to create pharmaceutical and cosmeceutical compositions

Abstract

The purpose was to determine content of the main active components — macro- and microelements — in thermal water, in the intermediate product (concentrate) and in the dosage form (spray). Determining the saturation of the dosage form with active components was the purpose as well. Materials and methods. Thermal water from the Nizhne-Paratunskiye springs of Kamchatka, concentrate from this water, composition with a concentrate of thermal water in the form of spray were used. Determination of the content of calcium and magnesium ions was carried out by titrimetric method on the basis of forming a complex compound with Trilon B. Validation of the used methods was carried out. Its repeatability was evaluated within one day to determine the precision of the technique. The intra- and inter-assay precision of the validated method was also evaluated. Solutions containing calcium and magnesium ions in concentrations of 80–120 % from the declared amount were prepared to determine linearity of the methods. Results. The content of magnesium and calcium ions in the raw material (3.63 and 284.41 mg/l, respectively), the intermediate product — concentrate (35.38 and 2723.00 mg/l) and the finished form — spray (11 and 778 mg/l) was determined. Conclusion. As a result of studies based on the determination of the content of macro- and microelements in the spray, concentrate, dosage form, it was found that it is possible to achieve an increase in the content of the trace elements in thermal water, thanks to its 10-fold concentration, which will reduce the cost of transportation. Using the concentrate it is possible to achieve the required salt concentration in the finished product. The developed spray has a complex of auxiliary substances that provide the required consistency of the composition, easily releases hydrothermal water, is chemically indifferent, compatible with salts, absorbs liquid well, is easily removed from the application site, leaves no traces.