Possibility of PET/CT in Patients’ with Extranodal Diffffuse Large B-Cell Lymphoma of Stomach at Difffferent Treatment Stages

Abstract

Introduction: Gastric extranodal diffuse large B-cell lymphoma (DLBCL) is one of the most common types of lymphoma. The management of patients with DLBCL of s tomach includes immunochemotherapy, radiotherapy and surgery, but there is no standard approach. Endoscopy as a part of diagnostic workup is obligatory, but using positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) is not obligatory at different stages of observation and treatment.Purpose: To evaluate the diagnostic precision of PET/CT with 18F-FDG in both assesement and treatment stages for patients with extranodal DLBCL of stomach. Materials and methods. In this study we describe early and late therapeutic outcomes of 23 patients with primary extranodal DLBCL of stomach, treated in our center between 2010 and 2018, who received R-CHOP immunochemotherapy regimen. There were PET/CT and fibrogastroduodenoscopy (EGD) provided for all patients on every stage of assessment.Results: The diagnostic accuracy of PET/CT before the treatment was 87 %, after immunochemotherapy — 91,3 %, after radiotherapy — 100 %.Conclusions: This study shows up the role of including PET/CT scan as an observation method for patients with extranodal DLBCL of stomach on each stage of treatment and response assessment, especially for long-term prognosis evaluation.