Abstract
Ovarian suppression (OS) is an effective therapy in hormone-sensitive breast cancer. Oophorectomy and ovarian irradiation have historically been used to achieve the goal of ovarian ablation. Luteinizing hormone releasing hormone (LHRH) analogues have largely supplanted surgical and radiation-based approaches because of less side effects and a lower likelihood of permanent amenorrhea, with the potential for restoration of fertility. LHRH analogues goserelin, buserelin, leuprorelin are equally effective. Buserelin is economically attractive.
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