Abstract
INTRODUCTION: The research is dedicated to the main features of brain angioarchitectonics caused by the development of Binswanger’s disease (BD), as well as to the effectiveness of the method of transcatheter laser revascularization of cerebral vessels in the treatment of this disease.MATERIALS: We examined 23 patients with BD whose age ranged from 58 to 81, mean age 78, including 15 (65.22%) men and 8 (34.78%) women. The examination included Clinical Dementia Rate (CDR), Mini-Mental State Examination (MMSE), Index Bartels (IB), laboratory examination, scintigraphy (SG), rheoencephalography (REG), Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and cerebral multi-gated angiography (MUGA).14 (60.87%) patients underwent transcatheter interventions - Test Group.9 (39.13%) patients had conservative treatment - Control Group.RESULTS: Test Group: favorable clinical result - 9 (64.29%) cases; adequate clinical result - 5 (35.71%) cases; comparatively adequate and comparatively positive clinical results were not attained in any case.Control Group: favorable and adequate clinical results were not achieved in any case; comparatively adequate clinical result was gained in 7 (77.78%) cases; comparatively positive clinical result - in 2 (22.23%) cases.CONCLUSIONS: The method of transcatheter laser revascularization of cerebral vessels furthers natural angiogenesis, induces collateral and capillary revascularization both in ischemic areas and in closely located tissues, thereby improving cerebral blood flow. At the same time, laser energy promotes the restoration of metabolic processes in neurons. It significantly distinguishes the proposed method from conservative treatment.
Highlights
The research is dedicated to the main features of brain angioarchitectonics caused by the development of Binswanger’s disease (BD), as well as to the effectiveness of the method of transcatheter laser revascularization of cerebral vessels in the treatment of this disease.Materials: We examined 23 patients with BD whose age ranged from 58 to 81, mean age 78, including 15 (65.22%) men and 8 (34.78%) women
Favorable clinical result after the treatment was defined as almost complete restoration of mental and motor functions and activities of daily living (MMSE 27-30, restoration of activities of daily living Index Bartels (IB) 90-100);
Adequate clinical result was defined as incomplete restoration of mental and motor functions and activities of daily living (MMSE 21-26, restoration of activities of daily living IB 75-85);
Summary
The research is dedicated to the main features of brain angioarchitectonics caused by the development of Binswanger’s disease (BD), as well as to the effectiveness of the method of transcatheter laser revascularization of cerebral vessels in the treatment of this disease.Materials: We examined 23 patients with BD whose age ranged from 58 to 81, mean age 78, including 15 (65.22%) men and 8 (34.78%) women. The research is dedicated to the main features of brain angioarchitectonics caused by the development of Binswanger’s disease (BD), as well as to the effectiveness of the method of transcatheter laser revascularization of cerebral vessels in the treatment of this disease. There has been a sufficiently rapid aging of the population, which causes an increase in the number of patients with cerebrovascular diseases complicated by neurodegenerative processes, cognitive impairment and dementia (Wilson et al, 2011; Wilson et al, 2013). When the blood supply is normal, the amount of capillaries in one cubic centimeter of the brain tissue is 3-4 thousand (Gjulev et al, 2002). Capillary blood supply disorders cause severe hemodynamic and ischemic disorders (Maksimovich, 2012). According to various authors, BD used to be a very rare disease, but its frequency makes 30% of all dementias (Tomimoto, 2011)
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