POSSIBILITIES AND PROSPECTS OF DOUBLE EFFECT DRUGS APPLICATION FOR SYSTEMIC OSTEOPOROSIS PHARMACOTHERAPY OF PATIENTS WITH BONE FRACTURES

A. Y. Kochish,T. B. Minasov,D. V. Stafeev,S. N. Ivanov

doi:10.21823/2311-2905-2012--2-99-104

Abstract

Scientific literature analysis shows that osteoporotic bone fractures appear to be actual and socially significant problem of modern medicine. Patients’ treatment with this pathology should be complex and include osteoporosis pharmacotherapy. The perspective drug for this case is strontium ranelate. Experimental and clinic researches show its positive influence on osteoporotic fractures healing, possibility to increase implants stability by osteosynthesis, moreover it can improve microarchitectonics of bone tissue and functional results of treatment of patients with such a pathology. However, strontium ranelate application efficiency with osteoporotic bone fractures patients requires further investigations.

Highlights

Scientific literature analysis shows that osteoporotic bone fractures appear to be actual and socially significant problem of modern medicine
Experimental and clinic researches show its positive influence on osteoporotic fractures healing, possibility to increase implants stability by osteosynthesis, it can improve microarchitectonics of bone tissue and functional results of treatment of patients with such a pathology
Результаты отдельных клинических исследований подтверждают данные экспериментальных работ и свидетельствуют об улучшении микроархитектоники костной ткани на фоне терапии ранелатом стронция, а также о его положительном влиянии на функциональные результаты лечения пациентов с остеопоротическими переломами костей

Summary

Introduction

Scientific literature analysis shows that osteoporotic bone fractures appear to be actual and socially significant problem of modern medicine. Experimental and clinic researches show its positive influence on osteoporotic fractures healing, possibility to increase implants stability by osteosynthesis, it can improve microarchitectonics of bone tissue and functional results of treatment of patients with such a pathology.

Results

Conclusion