Abstract
9606 Background: Serum squamous cell carcinoma antigen (SCC-Ag) elevation without detectable recurrent lesion during follow-up in cervical cancer patients presents a diagnostic and therapeutic challenge. We evaluated fluorine-18-labeled fluoro-2-deoxy-D-glucose positron emission tomography (PET) in this situation by a prospective trial. Methods: Women with cervical cancer, having completely responded to primary or salvage treatment, had serum SCC-Ag >= 2.0 ng/ml in two consecutive measures and had no evidence of recurrence detected by conventional studies were eligible. Patients with skin lesion(s), documented renal function impairment or pulmonary lesion(s) that might explain the SCC-Ag elevation were excluded. PET was undertaken within 2 weeks after conventional studies. Results: 27 consecutive patients were registered. Positive PET findings were showed in 19 patients: 14 with distant lesion(s), 2 with local lesion(s) and 3 with local and distant lesions. 17 patients with positive PET findings were conf...
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