Abstract

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [(68)Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

Highlights

  • We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical Positron emission tomography (PET) radiotracer, [68Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control

  • The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith

  • Silica-based monoliths have recently become popular for chromatography,[12] including quality control in pharmaceutical production,[13] and have proven successful in a variety of microfluidic applications.[14]

Read more

Summary

Introduction

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers† We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [68Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control.

Results
Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.