Abstract
Five of fifteen children with histologically proven neuronal migration disorders (NMD) and refractory localization-related epilepsy had surface positive spikes or sharp waves or both on scalp EEG performed preoperatively in a study at The Hospital for Sick Children, Toronto, Canada.
Highlights
Five of fifteen children with histologically proven neuronal migration disorders (NMD) and refractory localization-related epilepsy had surface positive spikes or sharp waves or both on scalp EEG performed preoperatively in a study at The Hospital for Sick Children, Toronto, Canada
Cortical hypometabolism and delayed myelination were reported in a study of 18 children with West syndrome at Nagoya University School of Medicine, Japan. (Natsume J, Watanabe K, Maeda N et al Epilepsia Dec 1996;37:1180-1184)
Lesions involving the rolandic fissure are more extended than those seen on the MRI and cannot be completely resected
Summary
Five of fifteen children with histologically proven neuronal migration disorders (NMD) and refractory localization-related epilepsy had surface positive spikes or sharp waves or both on scalp EEG performed preoperatively in a study at The Hospital for Sick Children, Toronto, Canada. Patients with positive epileptiform discharges had earlier onset of seizures with focal motor pattern, poor response to AEDs, a higher frequency of hemiparesis preoperatively, and surgery at a younger age with poor outcome. (Otsubo H, Steinlin M, Hwang PA, et al Positive epileptiform discharges in children with neuronal migration disorders.
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